Diseases of the adrenal cortex can be conveniently divided into those associated with cortical hyperfunction and those characterized by cortical hypofunction. The most important diseases of the adrenal medulla are neoplasms, which include neoplasms of chromaffin cells (pheochromocytomas) and neuronal neoplasms (including neuroblastomas and more mature ganglion cell tumors). Adrenals are also common siteS for secondary metastases from common primaries such as the lungs.